How to Naturally Increase GLP-1

Hint - it starts in the gut!

Glucagon-Like Peptide 1 (GLP-1), is a hormone that is getting a lot of attention for its role in glucose metabolism and appetite regulation. You've likely heard all of the buzz on these pharmaceutical injectables, such as Ozempic, and may even know someone who's taking one.

What if I told you that the gut microbiome may influence GLP-1 secretion and you can increase GLP-1 naturally by supporting your gut health. As you know, I'm always looking for the root cause - for the "why", instead of the band-aid approach.

Why are people low in GLP-1? It likely starts in the gut.

Dysbiosis, or an imbalance in the gut microbiome, has been associated with obesity, insulin resistance, and inflammation-conditions often linked to impaired GLP-1 signaling.

GLP-1 is a hormone primarily secreted by L-cells in the distal small intestine and colon in response to nutrient ingestion. It plays a crucial role in glucose homeostasis by enhancing insulin secretion from pancreatic beta cells, inhibiting glucagon release, and delaying gastric emptying. GLP-1 also exerts effects on the central nervous system, particularly in the hypothalamus, to regulate appetite and satiety.

SCFAs, such as acetate, propionate, and butyrate, are produced through microbial fermentation of dietary fibers and have been shown to regulate gut hormone release, including GLP-1.

This makes a diverse and balanced microbiome essential for optimal GLP-1 function.

Additionally, specific bacterial species have been linked to enhanced GLP-1 secretion. Bifidobacteria, Akkermansia muciniphila, and Clostridium butyricum are associated with a healthy gut microbiome and have been shown to increase GLP-1 levels in both animal models and human studies. These bacteria may modulate GLP-1 through their production of SCFAs and other bioactive compounds that interact with L-cells in the gut.

How to increase production of GLP-1

Increasing SFCAs in the gut is the best way to start enhancing GLP-1 secretion. Foods that increase butyrate include green bananas, plantains, cooked and cooled potatoes (eaten cold) which are all high in resistant starch. If you don't want to start eating a high amount of starchy foods, then you can also purchase green banana or plantain flour.

Interestingly, you also produce butyric acid when you are in ketosis whether that's from fasting or a ketogenic diet. I love the infinite wisdom of the human body always giving us what we need.

You can also take a supplement by BodyBio called Sodium Butyrate. It's available on Fullscript and if you create an account you can get 10% off. Order here.